Antigen Peptide Transporter 2 (TAP2)

ABC18; ABCB3; APT2; PSF2; RING11; Y1; ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter involved in antigen processing 2

SPN	T675
HGNC	44
MGI	98484
PubMed	24586191
RGD	3818
UniProt	Q03519
Wiki	TAP2

TAP2 is a a member of the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

Reference

"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]

"Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex."
Proc. Natl. Acad. Sci. U.S.A. 89:1463-1467(1992) [PubMed] [Europe PMC] [Abstract]

"Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region."
Proc. Natl. Acad. Sci. U.S.A. 88:10094-10098(1991) [PubMed] [Europe PMC] [Abstract]

"Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2."
Immunogenetics 37:373-380(1993) [PubMed] [Europe PMC] [Abstract]

"Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome."
Arthritis Rheum. 40:1685-1692(1997) [PubMed] [Europe PMC] [Abstract]

"Novel splicing of the human MHC-encoded peptide transporter confers unique properties."
J. Immunol. 162:852-859(1999) [PubMed] [Europe PMC] [Abstract]

"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain."
Tissue Antigens 45:139-142(1995) [PubMed] [Europe PMC] [Abstract]

"New TAP2 polymorphisms in Africans."
Tissue Antigens 51:556-562(1998) [PubMed] [Europe PMC] [Abstract]

"Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis."
Clin. Exp. Rheumatol. 12:29-33(1994) [PubMed] [Europe PMC] [Abstract]

"A viral inhibitor of peptide transporters for antigen presentation."
Nature 375:415-418(1995) [PubMed] [Europe PMC] [Abstract]

"Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site."
J. Immunol. 157:5467-5477(1996) [PubMed] [Europe PMC] [Abstract]

"Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47."
EMBO J. 15:3247-3255(1996) [PubMed] [Europe PMC] [Abstract]

"The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP."
Immunity 6:613-621(1997) [PubMed] [Europe PMC] [Abstract]

"The human cytomegalovirus gene product US6 inhibits ATP binding by TAP."
EMBO J. 20:387-396(2001) [PubMed] [Europe PMC] [Abstract]

"Adenovirus E19 has two mechanisms for affecting class I MHC expression."
J. Immunol. 162:5049-5052(1999) [PubMed] [Europe PMC] [Abstract]

"Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation."
J. Immunol. 182:2313-2324(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Allelic variants of the human putative peptide transporter involved in antigen processing."
Proc. Natl. Acad. Sci. U.S.A. 89:3932-3936(1992) [PubMed] [Europe PMC] [Abstract]

"Homozygous human TAP peptide transporter mutation in HLA class I deficiency."
Science 265:237-241(1994) [PubMed] [Europe PMC] [Abstract]

"Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans."
Genes Immun. 2:32-40(2001) [PubMed] [Europe PMC] [Abstract]