Protein Kinase C Eta (PKCh)

PRKCH; PRKC-H; PKC-L; PRKCL; NPKC-Eta

SPN	T673
HGNC	9403
MGI	97600
PubMed	9763653
RGD	621888
UniProt	P24723
Wiki	PRKCH

By screening a human keratinocyte cDNA library using PRKCA fragments as probes, Bacher et al. (1991) isolated a cDNA encoding PRKCH, which they called PKCL. The predicted PRKCH protein contains 680 amino acids and shows highest homology with PRKCE. PRKCH has a consensus ATP-binding site, a catalytic kinase domain, and a conserved cysteine-rich domain. Northern blot analysis of rat tissues detected a 4.2-kb transcript at highest levels in lung, with lower levels in heart and skin. The PRKCH transcript was also detected in the human skin carcinoma cell line SCL-1, the human epidermoid carcinoma cell line A431, and in HaCaT human skin keratinocytes. Transfection of COS cells with a PRKCH expression vector determined that this protein has phorbol ester-binding ability and kinase activity.

Reference

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Erratum
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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"A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction."
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