Hedgehog Homolog, Desert (DHH)
HHG3
Desert hedgehog protein is a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Hu01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Hu01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Hu01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Hu01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Hu01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Mu01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Mu01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Mu01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Mu01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Mu01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Ra01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Ra01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Ra01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Ra01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Ra01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Ca01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Ca01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Ca01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Ca01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Ca01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Po01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Po01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Po01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Po01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Po01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Bo01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Bo01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Bo01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Bo01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Bo01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Rb01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Rb01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Rb01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Rb01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Rb01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT669Mo01 | Recombinant Hedgehog Homolog, Desert (DHH) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT669Mo01 | Monoclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IP. |
| PAT669Mo01 | Polyclonal Antibody to Hedgehog Homolog, Desert (DHH) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT669Mo01 | CLIA Kit for Hedgehog Homolog, Desert (DHH) | CLIA assay for Antigen Detection |
| ELT669Mo01 | ELISA Kit for Hedgehog Homolog, Desert (DHH) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Expression of Sonic hedgehog and its receptor Patched/Smoothened in human cancer cell lines and embryonic organs."
J. Biochem. Mol. Biol. Biophys. 4:27-34(2000)
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy."
Am. J. Hum. Genet. 67:1302-1305(2000) [PubMed] [Europe PMC] [Abstract]
"Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP."
Nat. Struct. Mol. Biol. 16:698-703(2009) [PubMed] [Europe PMC] [Abstract]
"All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."
J. Biol. Chem. 285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]
"Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis."
J. Clin. Endocrinol. Metab. 89:4480-4483(2004) [PubMed] [Europe PMC] [Abstract]
Erratum
J. Clin. Endocrinol. Metab. 89:5453-5453(2004)