Interleukin 1 Eta (IL1h)

IL1F8; IL36b; FIL1; FIL1-(ETA); FIL1H; IL-1F8; IL-1H2; IL1-ETA; IL1H2; Interleukin 36, Beta; Interleukin-1 Family Member 8; Interleukin-1 homolog 2

SPN	T650
HGNC	15564
MGI	1916927
PubMed	18401833
RGD	1307847
UniProt	Q9NZH7
Wiki	IL1F8

Interleukin-1 family member 8 is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.The deduced 157-amino acid protein, like FIL1-delta, contains neither a signal peptide nor a prodomain. It shares 46% sequence identity with FIL1-epsilon. PCR analyses detected expression in tonsil, bone marrow, heart, placenta, lung, testis, and colon but not in other tissues or in any hematopoietic cell lines. Modeling indicated that FIL1-eta has a conserved 12-stranded beta-trefoil structure.

Reference

"Identification and initial characterization of four novel members of the interleukin-1 family."
J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]

"Four new members expand the IL-1 superfamily."
J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]

"A sequence-based map of the nine genes of the human interleukin-1 cluster."
Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes."
Arthritis Res. Ther. 8:R80-R80(2006) [PubMed] [Europe PMC] [Abstract]

"The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation."
Obesity 18:2234-2236(2010) [PubMed] [Europe PMC] [Abstract]

"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity."
J. Biol. Chem. 286:42594-42602(2011) [PubMed] [Europe PMC] [Abstract]

"IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression."
J. Immunol. 186:2613-2622(2011) [PubMed] [Europe PMC] [Abstract]

"Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis."
J. Invest. Dermatol. 131:2428-2437(2011) [PubMed] [Europe PMC] [Abstract]

"IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin."
J. Immunol. 192:6053-6061(2014) [PubMed] [Europe PMC] [Abstract]