Urocortin 1 (UCN1)
UI; UROC; Urocortin
Urocortin is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. Urocortin is a potent anorexigenic peptide of 40 amino acids that induces fed-like motor activity when administered centrally or peripherally in fasted animals. Urocortin belongs to the corticotropin-releasing factor (CRF) family that includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is also a potent and long-lasting hypotensive agent and increases coronary blood flow.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Hu01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Hu01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Hu01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Hu01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Hu01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Mu01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Mu01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Mu01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Mu01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Mu01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Ra01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Ra01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Ra01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Ra01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Ra01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Ca01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Ca01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Ca01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Ca01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Ca01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Po01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Po01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Po01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Po01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Po01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Bo01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Bo01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Bo01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Bo01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Bo01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Rb01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Rb01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Rb01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Rb01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Rb01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT645Mo01 | Recombinant Urocortin 1 (UCN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT645Mo01 | Monoclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IP. |
| PAT645Mo01 | Polyclonal Antibody to Urocortin 1 (UCN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT645Mo01 | CLIA Kit for Urocortin 1 (UCN1) | CLIA assay for Antigen Detection |
| ELT645Mo01 | ELISA Kit for Urocortin 1 (UCN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning and characterization of human urocortin."
Endocrinology 137:2167-2170(1996) [PubMed] [Europe PMC] [Abstract]
"The structures of the mouse and human urocortin genes (Ucn and UCN)."
Genomics 50:23-33(1998) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The skin produces urocortin."
J. Clin. Endocrinol. Metab. 85:815-823(2000) [PubMed] [Europe PMC] [Abstract]
"Urocortin 1 in colonic mucosa in patients with ulcerative colitis."
J. Clin. Endocrinol. Metab. 89:5352-5361(2004) [PubMed] [Europe PMC] [Abstract]
"Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]
"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]