Urocortin 3 (UCN3)

SCP; SPC; UCNIII; Stresscopin

SPN	T642
HGNC	17781
MGI	1932970
PubMed	12810578
RGD	1562213
UniProt	Q969E3
Wiki	UCN3

Urocortin-3 is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. The mature human SCP peptide sequence shares 72% identity with that of Takifugu rubripes and 57% identity with that of Tetraodon nigroviridis, a freshwater pufferfish. In human and fish, a stretch of 30 residues at the respective carboxy termini has an extended alpha-helical structure shared by all CRH family peptides.

Reference

"Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor."
Proc. Natl. Acad. Sci. U.S.A. 98:7570-7575(2001) [PubMed] [Europe PMC] [Abstract]

"Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Common and divergent structural features of a series of corticotropin releasing factor-related peptides."
J. Am. Chem. Soc. 129:16102-16114(2007) [PubMed] [Europe PMC] [Abstract]

"Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor."
J. Biol. Chem. 285:40351-40361(2010) [PubMed] [Europe PMC] [Abstract]