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Exoribonuclease 1 (ERI1)

THEX1; 3'HEXO; 3'-5' exonuclease ERI1; Histone mRNA 3'-end-specific exoribonuclease; Enhanced RNAi Three Prime mRNA Exonuclease Homolog 1

Metazoan replication-dependent histone mRNAs end in a highly conserved stem-loop structure that is required for regulation of histone mRNA stability and is bound by stem loop-binding protein (SLBP). Using the histone mRNA stem-loop sequence in RNA affinity purification assays, Dominski et al. (2003) isolated HEXO (histone mRNA end-specific exonuclease) protein from HeLa whole-cell extracts. They sequenced regions of HEXO protein using mass spectrometry and matched this protein to a full-length protein from a sequence database. HEXO encodes a 50-kD protein containing a SAP domain capable of recognizing AT-rich scaffold-attachment regions (SARs) in chromosomal DNA, and a exonuclease domain similar to those of DEDD exonuclease family members.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Hu01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Hu01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Hu01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Hu01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Hu01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Mu01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Mu01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Mu01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Mu01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Mu01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Ra01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Ra01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Ra01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Ra01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Ra01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Ca01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Ca01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Ca01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Ca01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Ca01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Po01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Po01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Po01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Po01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Po01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Bo01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Bo01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Bo01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Bo01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Bo01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Rb01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Rb01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Rb01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Rb01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Rb01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT620Mo01 Recombinant Exoribonuclease 1 (ERI1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT620Mo01 Monoclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IP.
PAT620Mo01 Polyclonal Antibody to Exoribonuclease 1 (ERI1) WB; IHC; ICC; IF.
Assay Kits CLT620Mo01 CLIA Kit for Exoribonuclease 1 (ERI1) CLIA assay for Antigen Detection
ELT620Mo01 ELISA Kit for Exoribonuclease 1 (ERI1) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A 3' exonuclease that specifically interacts with the 3' end of histone mRNA."
Mol. Cell 12:295-305(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans."
Nature 427:645-649(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA."
J. Biol. Chem. 281:30447-30454(2006) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP."
J. Mol. Biol. 343:305-312(2004) [PubMed] [Europe PMC] [Abstract]