Tyrosinase (TYR)
OCAIA; OCA1A; OCA1; CMM8; Oculocutaneous Albinism IA; Monophenol monooxygenase; Tumor rejection antigen AB
- Tyrosinase (EC 1.14.18.1) catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Kwon et al. screened a lambda-gt11 human melanocyte cDNA library with antibodies against hamster tyrosinase to isolate a clone for human tyrosinase. The deduced 548-amino acid protein has a molecular mass of 62,610 Da and contains glycosylation sites and histidine-rich sites that could be used for copper binding.
- OCA1 is the gene associated with albinism, an autosomal recessive disorder. Albinism occurs when something causes the OCA1 gene to function improperly. The locus of gene OCA1 may be written "11q1.4-q2.1", meaning it is on the long arm of chromosome 11, somewhere in the range of sub-band 4 of band 1, and sub-band 1 of band 2.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Hu01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Hu01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Hu01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Hu01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Hu01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Mu01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Mu01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Mu01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Mu01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Mu01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Ra01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Ra01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Ra01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Ra01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Ra01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Ca01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Ca01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Ca01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Ca01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Ca01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Po01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Po01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Po01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Po01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Po01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Bo01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Bo01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Bo01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Bo01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Bo01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Rb01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Rb01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Rb01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Rb01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Rb01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT575Mo01 | Recombinant Tyrosinase (TYR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT575Mo01 | Monoclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IP. |
| PAT575Mo01 | Polyclonal Antibody to Tyrosinase (TYR) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT575Mo01 | CLIA Kit for Tyrosinase (TYR) | CLIA assay for Antigen Detection |
| ELT575Mo01 | ELISA Kit for Tyrosinase (TYR) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Erratum
Proc. Natl. Acad. Sci. U.S.A. 85:6352-6352(1988)
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Proc. Natl. Acad. Sci. U.S.A. 88:5272-5276(1991) [PubMed] [Europe PMC] [Abstract]
"The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas."
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Am. J. Hum. Genet. 48:1159-1167(1991) [PubMed] [Europe PMC] [Abstract]
Erratum
Am. J. Hum. Genet. 49:696-696(1991)
"Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions."
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"Homozygous tyrosinase gene mutation in an American black with tyrosinase-negative (type IA) oculocutaneous albinism."
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"Non-random distribution of missense mutations within the human tyrosinase gene in type I (tyrosinase-related) oculocutaneous albinism."
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"Mutations of the tyrosinase gene in Indo-Pakistani patients with type I (tyrosinase-deficient) oculocutaneous albinism (OCA)."
Am. J. Hum. Genet. 53:1173-1179(1993) [PubMed] [Europe PMC] [Abstract]
"Mutations of the tyrosinase gene in patients with oculocutaneous albinism from various ethnic groups in Israel."
Am. J. Hum. Genet. 54:586-594(1994) [PubMed] [Europe PMC] [Abstract]
"Initiation codon mutation of the tyrosinase gene as a cause of human albinism."
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Am. J. Ophthalmol. 121:724-726(1996) [PubMed] [Europe PMC] [Abstract]
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Hum. Mol. Genet. 6:659-664(1997) [PubMed] [Europe PMC] [Abstract]
"Novel mutations of the tyrosinase (TYR) gene in type I oculocutaneous albinism (OCA1)."
Hum. Mutat. 10:171-174(1997) [PubMed] [Europe PMC] [Abstract]
"Mutations of the human tyrosinase gene associated with tyrosinase related oculocutaneous albinism (OCA1)."
Hum. Mutat. 12:433-434(1998) [PubMed] [Europe PMC] [Abstract]
Erratum
Hum. Mutat. 13:83-83(1999)
"Novel and recurrent mutations in the tyrosinase gene and the P gene in the German albino population."
Hum. Genet. 105:200-210(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Hum. Genet. 108:208-208(2001)
"Insertion/deletion mutations of type I oculocutaneous albinism in Chinese patients from Taiwan."
Hum. Mutat. 14:542-542(1999) [PubMed] [Europe PMC] [Abstract]
"Mutation analysis of the tyrosinase gene in oculocutaneous albinism."
Hum. Mutat. 17:352-352(2001) [PubMed] [Europe PMC] [Abstract]
"A novel mutation of the tyrosinase gene causing oculocutaneous albinism type 1 (OCA1)."
J. Dermatol. Sci. 28:102-105(2002) [PubMed] [Europe PMC] [Abstract]
"Detection of 53 novel DNA variations within the tyrosinase gene and accumulation of mutations in 17 patients with albinism."
Hum. Mutat. 23:630-631(2004) [PubMed] [Europe PMC] [Abstract]
"A genomewide association study of skin pigmentation in a South Asian population."
Am. J. Hum. Genet. 81:1119-1132(2007) [PubMed] [Europe PMC] [Abstract]
"Genetic determinants of hair, eye and skin pigmentation in Europeans."
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"A population-based study of autosomal-recessive disease-causing mutations in a founder population."
Am. J. Hum. Genet. 91:608-620(2012) [PubMed] [Europe PMC] [Abstract]
"DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics."
Hum. Mutat. 34:827-835(2013) [PubMed] [Europe PMC] [Abstract]
"Identification of a novel mutation (p.Ile198Thr) in gene TYR in a Pakistani family with nonsyndromic oculocutaneous albinism."
Clin. Exp. Dermatol. 39:646-648(2014) [PubMed] [Europe PMC] [Abstract]