Ghrelin/Obestatin Preprohormone (GHRL)

MTLRP; Preproghrelin; Growth Hormone Secretagogue Receptor Ligand; Appetite-regulating hormone; Growth hormone-releasing peptide; Motilin-related peptide

SPN	T529
HGNC	18129
MGI	1930008
PubMed	22369141
RGD	632283
UniProt	Q9UBU3
Wiki	Obestatin

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression.

Reference

"Ghrelin is a growth-hormone-releasing acylated peptide from stomach."
Nature 402:656-660(1999) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide."
Gastroenterology 119:395-405(2000) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human Ghrelin gene."
J. Endocr. Genet. 1:231-233(2000)

"Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing."
J. Biol. Chem. 278:64-70(2003) [PubMed] [Europe PMC] [Abstract]

"Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts."
BMC Genomics 8:298-298(2007) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor."
Trends Endocrinol. Metab. 12:118-122(2001) [PubMed] [Europe PMC] [Abstract]