G Protein Coupled Receptor Kinase 5 (GRK5)

GPRK5; G protein-coupled receptor kinase GRK5

SPN	T527
HGNC	4544
MGI	109161
PubMed	18425130
RGD	61985
UniProt	P34947
Wiki	GRK5

G protein-coupled receptor kinase 5 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).

Bullrich et al. (1995) used a rodent-human hybrid panel to map 2 newly identified members of the GRK family: GPRK5 and GPRK6 to 10q24-qter and 5q35, respectively. The hybrid cells containing parts of chromosomes 10 and 5 were used for the regionalization.

Reference

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"G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence."
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J. Biol. Chem. 285:12823-12830(2010) [PubMed] [Europe PMC] [Abstract]

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"G protein-coupled receptor kinase 5 phosphorylation of Hip regulates internalization of the chemokine receptor CXCR4."
Biochemistry 50:6933-6941(2011) [PubMed] [Europe PMC] [Abstract]

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Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

"A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure."
Nat. Med. 14:510-517(2008) [PubMed] [Europe PMC] [Abstract]