Cytochrome P450 1A2 (CYP1A2)

CP12; P3-450; P450(PA); Cytochrome P450,Family 1,Subfamily A,Polypeptide 2

SPN	T487
HGNC	2596
MGI	88589
PubMed	18398030
RGD	2459
UniProt	P05177
Wiki	CYP1A2

Cytochrome P450 1A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.

Reference

"Human P3(450): cDNA and complete amino acid sequence."
Nucleic Acids Res. 14:6773-6774(1986) [PubMed] [Europe PMC] [Abstract]

"Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA."
Proc. Natl. Acad. Sci. U.S.A. 83:6731-6735(1986) [PubMed] [Europe PMC] [Abstract]

"Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression."
Mol. Endocrinol. 3:1399-1408(1989) [PubMed] [Europe PMC] [Abstract]

"Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15."
J. Exp. Pathol. 3:1-17(1987) [PubMed] [Europe PMC] [Abstract]

"Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
Pharmacogenetics 11:1-6(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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Mol. Pharmacol. 29:405-410(1986) [PubMed] [Europe PMC] [Abstract]

"Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
DNA 4:395-400(1985) [PubMed] [Europe PMC] [Abstract]

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Arch. Biochem. Biophys. 422:23-30(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2."
J. Biol. Chem. 282:14348-14355(2007) [PubMed] [Europe PMC] [Abstract]

"Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese."
Drug Metab. Dispos. 27:98-101(1999) [PubMed] [Europe PMC] [Abstract]

"Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population."
Hum. Mutat. 17:355-356(2001) [PubMed] [Europe PMC] [Abstract]

"Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes."
J. Pharmacol. Exp. Ther. 308:300-306(2004) [PubMed] [Europe PMC] [Abstract]

"Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]

"Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population."
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"Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
Hum. Mutat. 25:196-206(2005) [PubMed] [Europe PMC] [Abstract]

"Coffee, CYP1A2 genotype, and risk of myocardial infarction."
JAMA 295:1135-1141(2006) [PubMed] [Europe PMC] [Abstract]