Proteasome Subunit Alpha Type 1 (PSMa1)

HC2; NU; PROS30; Proteasome(Prosome,Macropain)Subunit,Alpha Type,1; Macropain subunit C2; Multicatalytic endopeptidase complex subunit C2; Proteasome nu chain

SPN	T452
HGNC	9530
MGI	1347005
PubMed	10873386
RGD	61841
UniProt	P25786
Wiki	PSMA1

Proteasome subunit alpha type-1 is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits.

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.

Reference

"The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous."
Biochim. Biophys. Acta 1079:29-38(1991) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes)."
Biochim. Biophys. Acta 1089:95-102(1991) [PubMed] [Europe PMC] [Abstract]

"Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes."
Gene 120:235-242(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"Human proteasome subunits from 2-dimensional gels identified by partial sequencing."
Biochem. Biophys. Res. Commun. 205:1785-1789(1994) [PubMed] [Europe PMC] [Abstract]

"Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human."
Genomics Proteomics Bioinformatics 4:165-172(2006) [PubMed] [Europe PMC] [Abstract]

"The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice."
Proteomics 6:498-504(2006) [PubMed] [Europe PMC] [Abstract]

"Conserved signal peptide of Notch3 inhibits interaction with proteasome."
Biochem. Biophys. Res. Commun. 355:245-251(2007) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]

"Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics."
Breast Cancer Res. Treat. 104:21-30(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]