Kruppel Like Factor 2, Lung (KLF2)

LKLF; Lung krueppel-like factor

SPN	T414
HGNC	6347
MGI	1342772
PubMed	17141159
RGD	1359220
UniProt	Q9Y5W3
Wiki	KLF2

Mature single-positive (CD4+ or CD8+) T lymphocytes enter a 'resting' state in which they are proliferatively quiescent and relatively resistant to apoptosis. Anderson et al. (1995) identified and characterized the gene for a novel zinc finger transcription factor that they symbolized LKLF for 'lung Kruppel-like factor.'

Using 5-prime and 3-prime RACE on a melted GC-rich DNA fragment similar to mouse Lklf, Kozyrev et al. (1999) isolated a cDNA encoding KLF2, which they termed LKLF. Sequence analysis predicted that the 355-amino acid LKLF protein, which is 87% identical to the mouse protein, has N-terminal proline-rich repeats, a putative activation domain, a potential nuclear localization signal, and a C-terminal zinc finger domain.

Reference

"Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus."
FEBS Lett. 448:149-152(1999) [PubMed] [Europe PMC] [Abstract]

"cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor."
Genomics 60:78-86(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase."
J. Biol. Chem. 276:29299-29306(2001) [PubMed] [Europe PMC] [Abstract]