Kallikrein 12 (KLK12)

KLK-L5; KLKL5; Kallikrein-Related Peptidase 12; Kallikrein-like protein 5

SPN	T409
HGNC	6360
MGI	1916761
PubMed	17391064
RGD	1308975
UniProt	Q9UKR0
Wiki	KLK12

Kallikrein-12 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.In the second mRNA form, the last exon is split into 2 separate exons with an additional intervening intron, producing a deduced 254-amino acid protein with a predicted molecular mass of 27.1 kD. In the third mRNA form, the fourth exon is missing, producing a deduced 111-amino acid protein with a molecular mass of 12 kD. RT-PCR demonstrated that KLK12 is expressed primarily in salivary gland, stomach, uterus, trachea, prostate, thymus, lung, colon, brain, breast, and thyroid gland and at lower levels in testis, pancreas, small intestine, and spinal cord.

Reference

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Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]

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Trends Endocrinol. Metab. 11:54-60(2000) [PubMed] [Europe PMC] [Abstract]

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]