Kallikrein 14 (KLK14)

KLK-L6; Kallikrein-like protein 6

SPN	T407
HGNC	6362
MGI	2447564
PubMed	11309303
RGD	1308606
UniProt	Q9P0G3
Wiki	KLK14

Kallikrein-14 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined.Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

Highly expressed in CNS, bone marrow and fetal liver. Also expressed in breast, thyroid, kidney, colon, pancreas, spleen, prostate, uterus, small intestine, placenta and skeletal muscle. Among 40 tissues tested, the highest expression is detected in skin followed by breast and prostate (at protein level).

Reference

"Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies."
Cancer Res. 61:3425-3431(2001) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle."
Genomics 73:117-122(2001) [PubMed] [Europe PMC] [Abstract]

"Understanding the accuracy of statistical haplotype inference with sequence data of known phase."
Genet. Epidemiol. 31:659-671(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4."
J. Biol. Chem. 275:37397-37406(2000) [PubMed] [Europe PMC] [Abstract]

"Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer."
Am. J. Clin. Pathol. 119:346-355(2003) [PubMed] [Europe PMC] [Abstract]

"Enzymatic profiling of human kallikrein 14 using phage-display substrate technology."
Biol. Chem. 386:291-298(2005) [PubMed] [Europe PMC] [Abstract]

"A proteolytic cascade of kallikreins in the stratum corneum."
J. Invest. Dermatol. 124:198-203(2005) [PubMed] [Europe PMC] [Abstract]

"Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum."
Biol. Chem. 387:761-768(2006) [PubMed] [Europe PMC] [Abstract]

"Proteinase-activated receptors, targets for kallikrein signaling."
J. Biol. Chem. 281:32095-32112(2006) [PubMed] [Europe PMC] [Abstract]

"Quantification of eight tissue kallikreins in the stratum corneum and sweat."
J. Invest. Dermatol. 126:925-929(2006) [PubMed] [Europe PMC] [Abstract]

"Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14."
J. Biol. Chem. 282:2405-2422(2007) [PubMed] [Europe PMC] [Abstract]

"A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation."
J. Biol. Chem. 282:3640-3652(2007) [PubMed] [Europe PMC] [Abstract]

"Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin."
J. Biol. Chem. 283:3031-3041(2008) [PubMed] [Europe PMC] [Abstract]

"Major role of human KLK14 in seminal clot liquefaction."
J. Biol. Chem. 283:19561-19569(2008) [PubMed] [Europe PMC] [Abstract]

"Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases."
J. Invest. Dermatol. 128:18-25(2008) [PubMed] [Europe PMC] [Abstract]