Thioredoxin Reductase 2 (TrxR2)
TR; TXNRD2; TR3; SelZ; Thioredoxin Reductase Beta; Selenoprotein Z
- Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins.
- TrxR2 partially overlaps the COMT gene on chromosome 22.Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Hu01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Hu01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Hu01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Hu01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Hu01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Mu01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Mu01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Mu01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Mu01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Mu01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Ra01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Ra01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Ra01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Ra01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Ra01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Ca01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Ca01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Ca01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Ca01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Ca01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Po01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Po01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Po01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Po01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Po01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Bo01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Bo01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Bo01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Bo01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Bo01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Rb01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Rb01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Rb01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Rb01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Rb01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT405Mo01 | Recombinant Thioredoxin Reductase 2 (TrxR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT405Mo01 | Monoclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IP. |
| PAT405Mo01 | Polyclonal Antibody to Thioredoxin Reductase 2 (TrxR2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT405Mo01 | CLIA Kit for Thioredoxin Reductase 2 (TrxR2) | CLIA assay for Antigen Detection |
| ELT405Mo01 | ELISA Kit for Thioredoxin Reductase 2 (TrxR2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases."
J. Biol. Chem. 274:24522-24530(1999) [PubMed] [Europe PMC] [Abstract]
"Cloning, sequencing and functional expression of a novel human thioredoxin reductase."
FEBS Lett. 442:105-111(1999) [PubMed] [Europe PMC] [Abstract]
"Human mitochondrial thioredoxin reductase: cDNA cloning, expression and genomic organization."
Eur. J. Biochem. 261:405-412(1999) [PubMed] [Europe PMC] [Abstract]
"Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif."
J. Biol. Chem. 274:38147-38154(1999) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Heterogeneity within animal thioredoxin reductases: evidence for alternative first exon splicing."
J. Biol. Chem. 276:3106-3114(2001) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]