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Glucagon Like Peptide 1 Receptor (GLP1R)

The glucagon-like peptide 1 receptor (GLP1R) is a human gene which resides on chromosome 6.The protein encoded by this gene is a member of the glucagon receptor family of G protein-coupled receptors.GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon.GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently GLP1R has been suggested as a potential target for the treatment of diabetes.GLP1R is also expressed in the brain where it is involved in the control of appetite. Furthermore, mice which over express GLP1R display improved memory and learning.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Hu01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Hu01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Hu01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Hu01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Hu01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Mu01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Mu01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Mu01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Mu01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Mu01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Ra01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Ra01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Ra01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Ra01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Ra01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Ca01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Ca01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Ca01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Ca01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Ca01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Po01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Po01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Po01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Po01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Po01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Bo01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Bo01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Bo01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Bo01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Bo01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Rb01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Rb01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Rb01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Rb01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Rb01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPT306Mo01 Recombinant Glucagon Like Peptide 1 Receptor (GLP1R) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAT306Mo01 Monoclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IP.
PAT306Mo01 Polyclonal Antibody to Glucagon Like Peptide 1 Receptor (GLP1R) WB; IHC; ICC; IF.
Assay Kits CLT306Mo01 CLIA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) CLIA assay for Antigen Detection
ELT306Mo01 ELISA Kit for Glucagon Like Peptide 1 Receptor (GLP1R) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor."
Diabetes 42:1678-1682(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor."
Endocrinology 133:1907-1910(1993) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional expression of a human glucagon-like peptide-1 receptor."
Biochem. Biophys. Res. Commun. 196:141-146(1993) [PubMed] [Europe PMC] [Abstract]

"Signal transduction of the GLP-1-receptor cloned from a human insulinoma."
FEBS Lett. 348:7-13(1994) [PubMed] [Europe PMC] [Abstract]

"Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences."
FEBS Lett. 358:219-224(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene."
Peptides 18:617-624(1997) [PubMed] [Europe PMC] [Abstract]

"Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket."
Peptides 31:2289-2293(2010) [PubMed] [Europe PMC] [Abstract]

"Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase."
Mol. Biol. Rep. 39:4375-4381(2012) [PubMed] [Europe PMC] [Abstract]

"Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization."
PLoS ONE 7:E32675-E32675(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain."
J. Biol. Chem. 283:11340-11347(2008) [PubMed] [Europe PMC] [Abstract]