5-Hydroxytryptamine Receptor 4 (HTR4)

5-HT4; 5-HT4R; Serotonin Receptor 4; 5-HT4 Receptor

SPN	T288
HGNC	5299
MGI	109246
PubMed	12898568
RGD	2850
UniProt	Q13639
Wiki	HTR4

5-hydroxytryptamine receptor 4 is member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine).

The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined.The receptor is located in the alimentary tract, urinary bladder, heart and adrenal gland as well as the central nervous system (CNS).

Reference

"Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus."
J. Neurochem. 70:2252-2261(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase."
NeuroReport 8:3189-3195(1997) [PubMed] [Europe PMC] [Abstract]

"Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain."
Mol. Pharmacol. 55:910-920(1999) [PubMed] [Europe PMC] [Abstract]

"Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants."
Neuropharmacology 42:60-73(2002) [PubMed] [Europe PMC] [Abstract]

"Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)."
Naunyn Schmiedebergs Arch. Pharmacol. 369:616-628(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant."
J. Neurochem. 74:478-489(2000) [PubMed] [Europe PMC] [Abstract]

"Expression of serotonin receptor mRNAs in blood vessels."
FEBS Lett. 370:215-221(1995) [PubMed] [Europe PMC] [Abstract]

"Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling."
EMBO J. 28:2706-2718(2009) [PubMed] [Europe PMC] [Abstract]

"Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids."
Nat. Genet. 44:200-205(2012) [PubMed] [Europe PMC] [Abstract]