Heat Shock Protein Beta 7 (HSPb7)

HSP-B7; cvHSP; Cardiovascular HSP; Heat Shock 27kDa Protein 7; Cardiovascular heat shock protein

SPN	T276
HGNC	5249
MGI	1352494
PubMed	20843828
RGD	62021
UniProt	Q9UBY9

CVHSP encodes a deduced 170-amino acid protein with features of a small heat-shock protein, including an HSP20 (HSPB8) protein family motif and a conserved C-terminal domain. The minor CVHSP splice variants encode proteins of 175 and 68 amino acids.

Northern blot analysis detected a major transcript of 2.3 kb and minor transcripts of 1.2 and 1.6 kb in heart and skeletal muscle. RNA dot blot analysis detected high expression of CVHSP in adult and fetal heart and in skeletal muscle, with weaker expression in aorta. RT-PCR showed CVHSP expression in adipose as well. Western blot analysis detected a major 25-kD CVHSP protein and a less abundant 23-kD protein.

Reference

"Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues."
J. Biol. Chem. 274:36592-36600(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"HSPB7 is a SC35 speckle resident small heat shock protein."
Biochim. Biophys. Acta 1793:1343-1353(2009) [PubMed] [Europe PMC] [Abstract]