Amyloid Beta Precursor Protein Binding Protein A3 (APBA3)

X11L2; Mint3; APB-A3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3

SPN	T256
HGNC	580
MGI	1888527
PubMed	10574372
RGD	620846
UniProt	O96018
Wiki	APBA3

Amyloid beta A4 precursor protein-binding family A member 3 is member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.

Alzheimer disease (AD) is a progressive neurodegenerative disorder that is characterized by dementia, neuronal loss, and accumulation in the brain of extracellular beta-amyloid fibrils and intraneuronal neurofibrillary tangles. The major components of amyloid plaques are 40- to 42-amino acid beta-amyloid peptides (A-beta), which are derived from beta-amyloid precursor protein (APP) via proteolytic processing.

Reference

"X11L2, a new member of X11 protein family interacts with Alzheimer's beta-amyloid precursor protein."
Biochem. Biophys. Res. Commun. 255:663-667(1999) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein."
NeuroReport 10:2575-2578(1999) [PubMed] [Europe PMC] [Abstract]

"Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2."
Eur. J. Cell Biol. 77:161-165(1998) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1."
J. Biol. Chem. 284:30350-30359(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the PDZ domain of amyloid beta A4 precursor protein-binding family A member 3."
Submitted (APR-2008) to the PDB data bank