Prostaglandin Reductase 1 (PTGR1)
LTB4DH; ZADH3; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; Zinc Binding Alcohol Dehydrogenase Domain Containing 3; 15-oxoprostaglandin 13-reductase
- PTGR1 isan enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants.
- Leukotriene B(4) 12-hydroxydehydrogenase catalyzes the conversion of leukotriene B(4) into 12-oxo-leukotriene B(4), its less-active metabolite.The identity between the porcine and human sequences they obtained is 83.5% at the amino acid level and 84.7% at the nucleotide level. Both enzymes are highly homologous with a protein, AdRab-F, expressed only in adult rabbit small intestine
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Hu01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Hu01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Hu01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Hu01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Hu01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Mu01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Mu01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Mu01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Mu01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Mu01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Ra01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Ra01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Ra01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Ra01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Ra01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Ca01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Ca01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Ca01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Ca01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Ca01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Po01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Po01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Po01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Po01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Po01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Bo01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Bo01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Bo01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Bo01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Bo01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Rb01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Rb01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Rb01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Rb01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Rb01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT254Mo01 | Recombinant Prostaglandin Reductase 1 (PTGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT254Mo01 | Monoclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IP. |
| PAT254Mo01 | Polyclonal Antibody to Prostaglandin Reductase 1 (PTGR1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT254Mo01 | CLIA Kit for Prostaglandin Reductase 1 (PTGR1) | CLIA assay for Antigen Detection |
| ELT254Mo01 | ELISA Kit for Prostaglandin Reductase 1 (PTGR1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase."
J. Biol. Chem. 271:2844-2850(1996) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase."
Submitted (MAY-2005) to the PDB data bank
"Crystal structure of human leukotriene B4 12-hydroxydehydrogenase in complex with NADP and raloxifene."
Submitted (JAN-2011) to the PDB data bank