Cytochrome P450 26A1 (CYP26A1)

CP26; CYP26; P450RAI; P450RAI1; hP450RAI; Cytochrome P450 retinoic acid-inactivating 1; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome

SPN	T244
HGNC	2603
MGI	1096359
PubMed	19035346
RGD	620161
UniProt	O43174
Wiki	CYP26A1

Cytochrome P450 26A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.

Reference

"cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450."
J. Biol. Chem. 272:18538-18541(1997) [PubMed] [Europe PMC] [Abstract]

"Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells."
Cell Growth Differ. 9:629-637(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of cytochrome P450RAI (CYP26) in human fetal hepatic and cephalic tissues."
Biochem. Biophys. Res. Commun. 252:487-491(1998) [PubMed] [Europe PMC] [Abstract]