Cytochrome P450 24A1 (CYP24A1)
CP24; CYP24; P450-CC24; Vitamin D 24-Hydroxylase; 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial ; Cytochrome P450 Family 24 Subfamily A Polypeptide 1
CYP24A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain to form calcitroic acid.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Hu01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Hu01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Hu01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Hu01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Hu01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Mu01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Mu01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Mu01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Mu01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Mu01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Ra01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Ra01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Ra01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Ra01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Ra01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Ca01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Ca01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Ca01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Ca01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Ca01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Po01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Po01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Po01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Po01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Po01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Bo01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Bo01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Bo01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Bo01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Bo01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Rb01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Rb01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Rb01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Rb01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Rb01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT241Mo01 | Recombinant Cytochrome P450 24A1 (CYP24A1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT241Mo01 | Monoclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IP. |
| PAT241Mo01 | Polyclonal Antibody to Cytochrome P450 24A1 (CYP24A1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT241Mo01 | CLIA Kit for Cytochrome P450 24A1 (CYP24A1) | CLIA assay for Antigen Detection |
| ELT241Mo01 | ELISA Kit for Cytochrome P450 24A1 (CYP24A1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA."
Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993) [PubMed] [Europe PMC] [Abstract]
"Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis."
J. Biol. Chem. 280:20604-20611(2005) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements."
Biochim. Biophys. Acta 1263:1-9(1995) [PubMed] [Europe PMC] [Abstract]
"Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets."
J. Bone Miner. Res. 8:1397-1406(1993) [PubMed] [Europe PMC] [Abstract]
"Metabolism of vitamin D3 by cytochromes P450."
Front. Biosci. 10:119-134(2005) [PubMed] [Europe PMC] [Abstract]
"Mutations in CYP24A1 and idiopathic infantile hypercalcemia."
N. Engl. J. Med. 365:410-421(2011) [PubMed] [Europe PMC] [Abstract]