Cytochrome P450 5A1 (CYP5A1)

TBXAS1; TS; CYP5; THAS; TXAS; TXS; Thromboxane A Synthase 1(Platelet); Cytochrome P450 Family 5 Subfamily A Polypeptide 1

SPN	T235
HGNC	11609
MGI	98497
PubMed	11465543
RGD	3826
UniProt	P24557
Wiki	CYP5A1

CYP5A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity.

This endoplasmic reticulum membrane protein catalyzes the conversion of prostaglandin H₂ to thromboxane A₂, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.

Reference

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"Primary structure of human thromboxane synthase determined from the cDNA sequence."
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"Characterization of the human gene (TBXAS1) encoding thromboxane synthase."
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"Isolation of partial complementary DNA encoding human thromboxane synthase."
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"Immunoaffinity purification of human thromboxane synthase."
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Thesis (1990), University of Konstanz, Germany

"Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum."
J. Biol. Chem. 268:19483-19490(1993) [PubMed] [Europe PMC] [Abstract]

"Severe bleeding associated with defective thromboxane synthetase."
Lancet 1:157-157(1980) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
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"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)

"Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]

"Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
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"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)."
Nat. Genet. 40:284-286(2008) [PubMed] [Europe PMC] [Abstract]