Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5)
PTPSTEP; STEP; Neural-specific protein-tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase
Analyses of various regions of the rat brain demonstrated a 3-kb and a 4.4-kb mRNA. The 3-kb mRNA was highly enriched within the striatum relative to other brain areas and thus was termed 'striatum-enriched phosphatase' (STEP) by the authors. In contrast, the 4.4-kb message was most abundant in the cerebral cortex and rare in the striatum. These 2 messages appeared to be alternatively processed mRNA transcripts of a single gene. Sharma et al. (1995) isolated and characterized additional alternatively spliced transcripts of the STEP gene. STEP 46 is the full-length, 46-kD protein. STEP 20 did not have the conserved tyrosine phosphatase domain. STEP 61 has a 5-prime extended open reading frame that encodes a protein with a predicted molecular mass of 61 kD and contains a single tyrosine phosphatase domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Hu01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Hu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Hu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Hu01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Hu01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Mu01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Mu01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Mu01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Mu01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Mu01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Ra01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Ra01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Ra01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Ra01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Ra01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Ca01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Ca01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Ca01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Ca01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Ca01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Po01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Po01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Po01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Po01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Po01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Bo01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Bo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Bo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Bo01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Bo01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Rb01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Rb01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Rb01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Rb01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Rb01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT196Mo01 | Recombinant Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT196Mo01 | Monoclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IP. |
| PAT196Mo01 | Polyclonal Antibody to Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT196Mo01 | CLIA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | CLIA assay for Antigen Detection |
| ELT196Mo01 | ELISA Kit for Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci."
Genomics 28:442-449(1995) [PubMed] [Europe PMC] [Abstract]
"Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP."
Biochem. J. 440:115-125(2011) [PubMed] [Europe PMC] [Abstract]
"Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases."
Biochem. J. 395:483-491(2006) [PubMed] [Europe PMC] [Abstract]