Protein Tyrosine Phosphatase, Non Receptor Type 7 (PTPN7)

BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI; Hematopoietic protein-tyrosine phosphatase; Protein-tyrosine phosphatase LC-PTP

SPN	T194
HGNC	9659
MGI	2156893
PubMed	16441242
RGD	708516
UniProt	P35236
Wiki	PTPN7

Tyrosine-protein phosphatase non-receptor type 7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Reference

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