ATP Binding Cassette Transporter C11 (ABCC11)

ABC-C11; MRP8; EWWD; Multidrug resistance-associated protein 8

SPN	T154
HGNC	14639
PubMed	20718756
UniProt	Q96J66
Wiki	ABCC11

ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, an SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.

Reference

"Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12."
Gene 273:89-96(2001) [PubMed] [Europe PMC] [Abstract]

"Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12."
Biochem. Biophys. Res. Commun. 288:933-939(2001) [PubMed] [Europe PMC] [Abstract]

"MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer."
Mol. Med. 7:509-516(2001) [PubMed] [Europe PMC] [Abstract]

"MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine."
J. Biol. Chem. 278:29509-29514(2003) [PubMed] [Europe PMC] [Abstract]

"Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)."
Mol. Pharmacol. 67:545-557(2005) [PubMed] [Europe PMC] [Abstract]

"A SNP in the ABCC11 gene is the determinant of human earwax type."
Nat. Genet. 38:324-330(2006) [PubMed] [Europe PMC] [Abstract]