ATP Binding Cassette Transporter G8 (ABCG8)
ABC-G8; STSL; Gallbladder Disease 4; Sterolin 2; ATP-binding cassette sub-family G member 8
ABCG8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Hu01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Hu01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Hu01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Hu01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Hu01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Mu01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Mu01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Mu01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Mu01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Mu01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Ra01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Ra01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Ra01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Ra01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Ra01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Ca01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Ca01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Ca01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Ca01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Ca01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Po01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Po01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Po01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Po01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Po01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Bo01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Bo01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Bo01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Bo01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Bo01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Rb01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Rb01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Rb01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Rb01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Rb01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT128Mo01 | Recombinant ATP Binding Cassette Transporter G8 (ABCG8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT128Mo01 | Monoclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IP. |
| PAT128Mo01 | Polyclonal Antibody to ATP Binding Cassette Transporter G8 (ABCG8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT128Mo01 | CLIA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | CLIA assay for Antigen Detection |
| ELT128Mo01 | ELISA Kit for ATP Binding Cassette Transporter G8 (ABCG8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters."
Science 290:1771-1775(2000) [PubMed] [Europe PMC] [Abstract]
"Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively."
Am. J. Hum. Genet. 69:278-290(2001) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"Role of ABCG1 and other ABCG family members in lipid metabolism."
J. Lipid Res. 42:1513-1520(2001) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia."
Hum. Mutat. 18:359-360(2001) [PubMed] [Europe PMC] [Abstract]
"Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."
J. Hum. Genet. 47:285-310(2002) [PubMed] [Europe PMC] [Abstract]
"A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease."
Nat. Genet. 39:995-999(2007) [PubMed] [Europe PMC] [Abstract]