Phosphatidic Acid Phosphatase Type 2B (PPAP2B)

Dri42; LPP3; PAP-2b; PAP2-b; PAP2-beta; VCIP; Lipid phosphate phosphohydrolase 3; Vascular endothelial growth factor and type I collagen-inducible protein

SPN	T087
HGNC	9229
MGI	1915166
PubMed	17610274
RGD	620454
UniProt	O14495
Wiki	PPAP2B

Lipid phosphate phosphohydrolase 3 is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D.

This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. Alternatively spliced transcript variants encoding the same protein have been described.

Reference

"Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase."
J. Biol. Chem. 272:24572-24578(1997) [PubMed] [Europe PMC] [Abstract]

"Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform."
J. Biol. Chem. 273:22059-22067(1998) [PubMed] [Europe PMC] [Abstract]

"Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP."
EMBO J. 22:1539-1554(2003) [PubMed] [Europe PMC] [Abstract]

"Large-scale concatenation cDNA sequencing."
Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Lipid phosphate phosphatases dimerise, but this interaction is not required for in vivo activity."
BMC Biochem. 5:2-2(2004) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]