Runt Related Transcription Factor 3 (RUNX3)

AML2; CBFA3; PEBP2aC; PEBP2A3; Acute myeloid leukemia 2 protein; Core-binding factor subunit alpha-3; Polyomavirus enhancer-binding protein 2 alpha C subunit

SPN	T036
HGNC	10473
MGI	102672
PubMed	14765120
RGD	620082
UniProt	Q13761
Wiki	RUNX3

RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.

Reference

"Cloning, mapping and expression of PEBP2 alpha C, a third gene encoding the mammalian Runt domain."
Gene 159:245-248(1995) [PubMed] [Europe PMC] [Abstract]

"AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization."
Genomics 23:425-432(1994) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog, CBFA3, to chromosome 1p35-pter."
Genomics 26:611-614(1995) [PubMed] [Europe PMC] [Abstract]

"Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors."
Proc. Natl. Acad. Sci. U.S.A. 95:11590-11595(1998) [PubMed] [Europe PMC] [Abstract]

"RUNX1 associates with histone deacetylases and SUV39H1 to repress transcription."
Oncogene 25:5777-5786(2006) [PubMed] [Europe PMC] [Abstract]

"Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1."
Nature 446:685-689(2007) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm."
J. Biol. Chem. 285:10122-10129(2010) [PubMed] [Europe PMC] [Abstract]