High Mobility Group Protein 20B (HMG20B)
BRAF35; HMGX2; SMARCE1r; SOXL; Sox-like transcriptional factor; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
High mobility group (HMG) proteins are nonhistone chromosomal proteins that contain a conserved DNA-binding domain called the HMG box.BRAF35 protein contains a nonspecific DNA-binding HMG domain and a kinesin-like coiled-coil domain. The only protein with structural domains similar to those of BRAF35 was BAF57, a subunit of the SWI/SNF complex. In situ hybridization showed that similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos were highest in proliferating tissues with high mitotic index. Strikingly, nuclear staining revealed a close association of the BRAF35-BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation. Antibody microinjection experiments suggested a role for the BRCA2-BRAF35 complex in modulation of cell cycle progression.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Hu01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Hu01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Hu01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Hu01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Hu01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Mu01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Mu01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Mu01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Mu01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Mu01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Ra01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Ra01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Ra01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Ra01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Ra01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Ca01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Ca01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Ca01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Ca01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Ca01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Po01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Po01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Po01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Po01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Po01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Bo01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Bo01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Bo01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Bo01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Bo01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Rb01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Rb01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Rb01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Rb01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Rb01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPT014Mo01 | Recombinant High Mobility Group Protein 20B (HMG20B) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAT014Mo01 | Monoclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IP. |
| PAT014Mo01 | Polyclonal Antibody to High Mobility Group Protein 20B (HMG20B) | WB; IHC; ICC; IF. | |
| Assay Kits | CLT014Mo01 | CLIA Kit for High Mobility Group Protein 20B (HMG20B) | CLIA assay for Antigen Detection |
| ELT014Mo01 | ELISA Kit for High Mobility Group Protein 20B (HMG20B) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression."
Cytogenet. Cell Genet. 88:62-67(2000) [PubMed] [Europe PMC] [Abstract]
"A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression."
Cell 104:247-257(2001) [PubMed] [Europe PMC] [Abstract]
"Characterization of human SMARCE1r high-mobility-group protein."
Biochim. Biophys. Acta 1574:269-276(2002) [PubMed] [Europe PMC] [Abstract]
"Cloning a cDNA encoding an alternatively spliced protein of BRCA2-associated factor 35."
Biochem. Biophys. Res. Commun. 295:129-135(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes."
Proc. Natl. Acad. Sci. U.S.A. 99:7420-7425(2002) [PubMed] [Europe PMC] [Abstract]
"A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes."
J. Biol. Chem. 278:7234-7239(2003) [PubMed] [Europe PMC] [Abstract]