Thrombospondin 4 (THBS4)

TSP4

SPN	S950
HGNC	11788
MGI	1101779
PubMed	23420636
RGD	62046
UniProt	P35443
Wiki	THBS4

Thrombospondin 4 (THBS4) was originally identified from a Xenopus stage 45 cDNA library.Overall, the 961-amino acid predicted protein is 73% identical to the X. laevis sequence; however, the C-terminal 220 residues are over 92% identical. The TSP4 mRNA is approximately 3.4 kb. In contrast to thrombospondin-4 of Xenopus laevis, the human protein contains an RGD (arg-gly-asp) cell-binding sequence in the third type 3 repeat.

Transfection of mouse NIH 3T3 fibroblasts or C2C12 myoblasts with a full-length human thrombospondin-4 cDNA resulted in the expression of a polypeptide with a reduced molecular weight of 140,000. In the absence of reducing agent, the expressed protein had an apparent molecular weight of 550,000.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Hu01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Hu01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Hu01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Hu01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Hu01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Mu01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Mu01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Mu01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Mu01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Mu01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Ra01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Ra01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Ra01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Ra01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Ra01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Ca01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Ca01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Ca01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Ca01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Ca01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Po01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Po01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Po01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Po01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Po01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Bo01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Bo01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Bo01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Bo01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Bo01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Rb01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Rb01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Rb01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Rb01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Rb01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS950Mo01	Recombinant Thrombospondin 4 (THBS4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS950Mo01	Monoclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IP.
Antibodies	PAS950Mo01	Polyclonal Antibody to Thrombospondin 4 (THBS4)	WB; IHC; ICC; IF.
Assay Kits	CLS950Mo01	CLIA Kit for Thrombospondin 4 (THBS4)	CLIA assay for Antigen Detection
Assay Kits	ELS950Mo01	ELISA Kit for Thrombospondin 4 (THBS4)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The evolution of the thrombospondin gene family."
J. Mol. Evol. 36:509-516(1993) [PubMed] [Europe PMC] [Abstract]

"Characterization of human thrombospondin-4."
J. Biol. Chem. 270:2809-2814(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity."
J. Cell. Physiol. 220:672-679(2009) [PubMed] [Europe PMC] [Abstract]

"A thrombospondin-dependent pathway for a protective ER stress response."
Cell 149:1257-1268(2012) [PubMed] [Europe PMC] [Abstract]

"ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response."
Circ. Res. 112:9-12(2013) [PubMed] [Europe PMC] [Abstract]

Erratum
Circ. Res. 112:E31-E31(2013)

"Thrombospondins: old players, new games."
Curr. Opin. Lipidol. 24:401-409(2013) [PubMed] [Europe PMC] [Abstract]

"Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels."
Thromb. Haemost. 106:1170-1178(2011) [PubMed] [Europe PMC] [Abstract]