Phospholipase C Delta 1 (PLCd1)

PLC-III; Phospholipase C-delta-1; Phosphoinositide phospholipase C-delta-1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

SPN	S937
HGNC	9060
MGI	97614
PubMed	22576628
RGD	3346
UniProt	P51178
Wiki	PLCD1

By screening a human aortic smooth muscle cDNA library with a probe derived from a rat C6 glioma cell PLC-delta-1 cDNA, Cheng et al. (1995) cloned a PLCD1 cDNA. The deduced 756-amino acid protein shares 95% sequence homology with the rat protein. It contains a pleckstrin homology (PH) domain and the conserved X and Y domains of PLC proteins. It is distinguished from PLC-gamma by lack of the SH2 and SH3 domains that are essential for activation of PLC-gamma by tyrosine protein kinases, and from PLC-beta by lack of the C-terminal region of PLC-beta that is responsible for binding and activation by G proteins. Northern blot analysis detected ubiquitous expression of a 3.8-kb transcript, with highest expression in lung, heart, pancreas, skeletal muscle, and kidney.

Reference

"Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis."
J. Biol. Chem. 270:5495-5505(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Hereditary leukonychia, or porcelain nails, resulting from mutations in PLCD1."
Am. J. Hum. Genet. 88:839-844(2011) [PubMed] [Europe PMC] [Abstract]