Phospholipase C Epsilon 1 (PLCe1)

PLCE; NPHS3; PPLC; Phosphoinositide phospholipase C-epsilon-1; Pancreas-enriched phospholipase C; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

SPN	S934
HGNC	17175
MGI	1921305
PubMed	20591883
RGD	69424
UniProt	Q9P212
Wiki	PLCE1

PLCe1 is a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Reference

"Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras."
J. Biol. Chem. 276:2752-2757(2001) [PubMed] [Europe PMC] [Abstract]

"A novel bifunctional phospholipase C that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway."
J. Biol. Chem. 276:2758-2765(2001) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling."
J. Biol. Chem. 276:30301-30307(2001) [PubMed] [Europe PMC] [Abstract]

"A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase."
Nat. Cell Biol. 3:1020-1024(2001) [PubMed] [Europe PMC] [Abstract]

"Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B."
J. Biol. Chem. 277:16805-16813(2002) [PubMed] [Europe PMC] [Abstract]

"Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon."
Oncogene 21:8105-8113(2002) [PubMed] [Europe PMC] [Abstract]

"Activation of CD4 T cells by Raf-independent effectors of Ras."
Proc. Natl. Acad. Sci. U.S.A. 100:6003-6008(2003) [PubMed] [Europe PMC] [Abstract]

"Inhibition of phospholipase C-epsilon by Gi-coupled receptors."
Cell. Signal. 16:921-928(2004) [PubMed] [Europe PMC] [Abstract]

"Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy."
Circ. Res. 97:1305-1313(2005) [PubMed] [Europe PMC] [Abstract]

"Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants."
Oncogene 24:90-100(2005) [PubMed] [Europe PMC] [Abstract]

"The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon."
J. Cell Sci. 119:1307-1319(2006) [PubMed] [Europe PMC] [Abstract]

"Structural and mechanistic insights into ras association domains of phospholipase C epsilon."
Mol. Cell 21:495-507(2006) [PubMed] [Europe PMC] [Abstract]

"Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible."
Nat. Genet. 38:1397-1405(2006) [PubMed] [Europe PMC] [Abstract]