Phospholipase D2 (PLD2)

PLD1C; Choline Phosphatase 2; Phosphatidylcholine-hydrolyzing phospholipase D2

SPN	S932
HGNC	9068
MGI	892877
PubMed	9761774
RGD	3350
UniProt	O14939
Wiki	PLD2

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. Northern blot analysis demonstrated expression of an approximately 3.5-kb PLD2 transcript in various tissues including heart, placenta, pancreas, spleen, thymus, prostate, uterus, brain, lung, kidney, small intestine, and colon. Expression was relatively low in liver and skeletal muscle. An additional 3.8-kb transcript was expressed in peripheral blood leukocytes.

Reference

"Characterization of human PLD2 and the analysis of PLD isoform splice variants."
FASEB J. 12:1309-1317(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2."
J. Biol. Chem. 273:12846-12852(1998) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity."
EMBO J. 19:5440-5449(2000) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]