Phospholipase A2 Receptor 1 (PLA2R1)

CLEC13C; PLA2G1R; PLA2IR; PLA2R; 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; Soluble secretory phospholipase A2 receptor

SPN	S925
HGNC	9042
MGI	102468
PubMed	23994771
RGD	1309777
UniProt	Q13018
Wiki	PLA2R1

Sequence analysis revealed that the deduced 1,465-amino acid PLA2R1 transmembrane protein contains a 25-amino acid signal sequence, 15 potential N-glycosylation sites, an N-terminal cysteine-rich domain, a fibronectin-like type II domain, 8 carbohydrate recognition domains, and a short C-terminal cytoplasmic tail containing a consensus sequence (asn-pro-X-tyr) also found in bovine Pla2r1. A casein-kinase II phosphorylation site is also located in this C-terminal region. Ancian et al. (1995) identified a splice variant encoding a soluble form of PLA2R1. Quantitative PCR analysis suggested that the ratio for the transcription of membrane to soluble PLA2R1 is 1.6. Northern blot analysis detected strong expression of 6.5- and 5.4-kb PLA2R1 transcripts in kidney, with moderate expression in placenta, lung, and skeletal muscle.

Reference

"The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization."
J. Biol. Chem. 270:8963-8970(1995) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals."
Eur. J. Biochem. 225:375-382(1994) [PubMed] [Europe PMC] [Abstract]

"Distribution of the phospholipase A2 receptor messenger RNA in human gestational tissues."
Placenta 19:35-40(1998) [PubMed] [Europe PMC] [Abstract]

"Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor."
J. Immunol. 174:464-474(2005) [PubMed] [Europe PMC] [Abstract]