Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10)
PRO940; SLG2; Sialic Acid Binding Ig-Like Lectin 10 Ig-Like Lectin 7; Siglec-Like Gene 2
By searching an EST database for sequences resembling CD33 (SIGLEC3) and screening a spleen cDNA library, Munday et al. (2001) isolated a cDNA encoding SIGLEC10. Sequence analysis predicted that the 697-amino acid SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and 4 C2-set Ig-like domains, 5 potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Hu01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Hu01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Hu01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Hu01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Hu01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Mu01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Mu01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Mu01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Mu01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Mu01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Ra01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Ra01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Ra01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Ra01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Ra01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Ca01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Ca01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Ca01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Ca01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Ca01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Po01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Po01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Po01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Po01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Po01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Bo01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Bo01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Bo01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Bo01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Bo01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Rb01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Rb01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Rb01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Rb01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Rb01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS867Mo01 | Recombinant Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS867Mo01 | Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IP. |
| PAS867Mo01 | Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS867Mo01 | CLIA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | CLIA assay for Antigen Detection |
| ELS867Mo01 | ELISA Kit for Sialic Acid Binding Ig Like Lectin 10 (SIGLEC10) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular characterization, tissue expression, and mapping of a novel Siglec-like gene (SLG2) with three splice variants."
Biochem. Biophys. Res. Commun. 284:900-910(2001) [PubMed] [Europe PMC] [Abstract]
"Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor."
Biochem. J. 355:489-497(2001) [PubMed] [Europe PMC] [Abstract]
"Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells."
J. Biol. Chem. 276:28106-28112(2001) [PubMed] [Europe PMC] [Abstract]
"Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1."
Biochem. Biophys. Res. Commun. 296:355-362(2002) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]