Proteasome Assembly Chaperone 2 (PSMG2)

HCCA3; CLAST3; PAC2; TNFSF5IP1; TNF Superfamily,Member 5-Induced Protein 1; Hepatocellular Carcinoma Susceptibility Protein; CD40 Ligand-Activated Specific Transcript 3

SPN	S854
HGNC	24929
MGI	1922901
PubMed	23480694
RGD	1304867
UniProt	Q969U7

CLAST3 expression increased in human and mouse B cells upon activation. In synchronized mouse fibroblasts, Clast3 expression was low in G1-arrested cells and increased during S and G2-M phases.

The deduced 264-amino acid protein contains 2 N-glycosylation sites, 3 N-myristoylation sites, and several phosphorylation sites. Northern blot analysis detected a 1.7-kb HCCA3 transcript in all tissues examined. Expression was high in lung, brain, and colon, moderate in muscle, stomach, spleen, and heart, and weak in small intestine, pancreas, and liver. Elevated HCCA3 expression in hepatocellular carcinoma was associated with tumor invasiveness and metastasis, but not with tumor size, degree of differentiation, or other parameters.

Reference

"Gene expression in CD34(+) cells from normal bone marrow and leukemic origins."
Hematol. J. 1:206-217(2000) [PubMed] [Europe PMC] [Abstract]

"Expression of liver cancer associated gene HCCA3."
World J. Gastroenterol. 7:821-825(2001) [PubMed] [Europe PMC] [Abstract].

"A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes."
Nature 437:1381-1385(2005) [PubMed] [Europe PMC] [Abstract]

"20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals."
Mol. Cell 27:660-674(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]