Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2)

HZF2; BD73; EAR-1r; RVR; Rev-ErbA Beta; Orphan nuclear hormone receptor BD73; Rev-erb alpha-related receptor; V-erbA-related protein 1-related

SPN	S843
HGNC	7963
MGI	2449205
PubMed	22460951
RGD	628828
UniProt	Q14995
Wiki	NR1D2

Rev-ErbA beta is a member of the Rev-ErbA family of transcription factors. Rev-erbβ, like Rev-erbα, belongs to the nuclear receptor superfamily and can modulate gene expression by directly binding to their promoters.Rev-erbβ is similar to Rev-erbα in its protein structure and function as a transcriptional repressor. The crystal structure of an unliganded Rev-erbβ ligand-binding domain (LBD) has been resolved (see figure to the right) and shows an extremely small ligand-binding pocket. However, Rev-erbβ has been shown to interact with heme, which appears important for its function.The structure of Rev-erbβ complexed with heme (see figure to the left) shows a substantial movement of helices 1 (N-terminus ) and 11 (C-terminus ) which opens up a large binding pocket in the interior of the protein that is able to accommodate this ligand.

Reference

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