RAR Related Orphan Receptor Alpha (RORa)

ROR1; ROR2; NR1F1; ROR3; RZRA; Nuclear receptor subfamily 1 group F member 1; Retinoid-related orphan receptor-alpha

SPN	S842
HGNC	10258
MGI	104661
PubMed	21359227
UniProt	P35398
Wiki	RORA

ROR-alpha), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor encoded by the RORA gene.

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Four transcript variants encoding different isoforms have been described for this gene.

Reference

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

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Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]

"Coactivators for the orphan nuclear receptor RORalpha."
Mol. Endocrinol. 13:1550-1557(1999) [PubMed] [Europe PMC] [Abstract]

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"The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response."
EMBO Rep. 2:42-48(2001) [PubMed] [Europe PMC] [Abstract]

"Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha."
J. Biol. Chem. 276:2865-2871(2001) [PubMed] [Europe PMC] [Abstract]

"The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation."
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"Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1."
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"Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORalpha."
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"Identification of the human ApoAV gene as a novel RORalpha target gene."
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"RORA, a large common fragile site gene, is involved in cellular stress response."
Oncogene 25:2901-2908(2006) [PubMed] [Europe PMC] [Abstract]

"Extracellular signal-regulated kinase-2 phosphorylates RORalpha4 in vitro."
Biochem. Biophys. Res. Commun. 358:890-896(2007) [PubMed] [Europe PMC] [Abstract]

"Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
Arterioscler. Thromb. Vasc. Biol. 28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]

"Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3."
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"Phosphorylation and transcriptional activity regulation of retinoid-related orphan receptor alpha 1 by protein kinases C."
J. Neurochem. 104:1321-1332(2008) [PubMed] [Europe PMC] [Abstract]

"SUMOylation of RORalpha potentiates transcriptional activation function."
Biochem. Biophys. Res. Commun. 378:513-517(2009) [PubMed] [Europe PMC] [Abstract]

"Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
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"Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]

"Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)."
J. Biol. Rhythms 26:187-199(2011) [PubMed] [Europe PMC] [Abstract]

"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."
Nature 472:491-494(2011) [PubMed] [Europe PMC] [Abstract]

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

"EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex."
Mol. Cell 48:572-586(2012) [PubMed] [Europe PMC] [Abstract]

"Action of RORs and their ligands in (patho)physiology."
Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"X-ray structure of the hRORalpha LBD at 1.63 A: structural and functional data that cholesterol or a cholesterol derivative is the natural ligand of RORalpha."
Structure 10:1697-1707(2002) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A."
J. Biol. Chem. 279:14033-14038(2004) [PubMed] [Europe PMC] [Abstract]