RAR Related Orphan Receptor Gamma (RORg)

RORC; NR1F3; RORG; RZRG; TOR; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma

SPN	S840
HGNC	10260
MGI	104856
PubMed	21948370
RGD	1595785
UniProt	P51449

RORγ is expressed in many tissues, including thymus, lung, liver, kidney, muscle, and brown fat. While RORγ mRNA is abundantly expressed, attempts to detect RORγ protein have not been successful therefore it is not clear whether RORγ protein is actually expressed. Consistent with this, the main phenotypes identified in RORγ knockout mice (where neither isoform is expressed) are those associated with RORγt immune system function and an isoform specific RORγt knockout displayed a phenotype identical to the RORγ knockout. On the other hand, circadian phenotypes of RORγ mice in tissues where the RORγt isoform is expressed in minute amounts argues for the expression of functional RORγ isoform. Absent protein in previous studies may be due to the high amplitude circadian rhythm of expression of this isoform in some tissues.

Reference

"ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle."
Biochem. Biophys. Res. Commun. 205:1976-1983(1994) [PubMed] [Europe PMC] [Abstract]

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BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function."
Nature 453:236-240(2008) [PubMed] [Europe PMC] [Abstract]

"Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
Nucl. Recept. Signal. 7:3-35(2009) [PubMed] [Europe PMC] [Abstract]

"A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol)."
Biochim. Biophys. Acta 1801:917-923(2010) [PubMed] [Europe PMC] [Abstract]

"Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
J. Biol. Chem. 285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]

"Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma."
EMBO Mol. Med. 3:637-651(2011) [PubMed] [Europe PMC] [Abstract]

"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."
Nature 472:491-494(2011) [PubMed] [Europe PMC] [Abstract]

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Nature 480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

"Action of RORs and their ligands in (patho)physiology."
Trends Endocrinol. Metab. 23:619-627(2012) [PubMed] [Europe PMC] [Abstract]

"Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma."
Mol. Endocrinol. 24:923-929(2010) [PubMed] [Europe PMC] [Abstract]