Testicular Receptor 2 (TR2)

NR2C1; Nuclear Receptor Subfamily 2,Group C,Member 1; Orphan nuclear receptor TR2

SPN	S836
HGNC	7971
MGI	1352465
PubMed	12052874
UniProt	P13056
Wiki	NR2C1

NR2C1 is a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.Dot blot hybridization indicated that TR2-5 mRNA levels increased after castration of rats and that this increase was reversed by 5-alpha-dihydrotestosterone injection. Expression of TR2-5 resulted in a 52-kD protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Hu01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Hu01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Hu01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Hu01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Hu01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Mu01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Mu01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Mu01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Mu01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Mu01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Ra01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Ra01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Ra01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Ra01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Ra01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Ca01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Ca01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Ca01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Ca01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Ca01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Po01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Po01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Po01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Po01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Po01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Bo01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Bo01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Bo01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Bo01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Bo01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Rb01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Rb01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Rb01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Rb01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Rb01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS836Mo01	Recombinant Testicular Receptor 2 (TR2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS836Mo01	Monoclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IP.
Antibodies	PAS836Mo01	Polyclonal Antibody to Testicular Receptor 2 (TR2)	WB; IHC; ICC; IF.
Assay Kits	CLS836Mo01	CLIA Kit for Testicular Receptor 2 (TR2)	CLIA assay for Antigen Detection
Assay Kits	ELS836Mo01	ELISA Kit for Testicular Receptor 2 (TR2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of a new member of the steroid receptor super-family by cloning and sequence analysis."
Biochem. Biophys. Res. Commun. 155:971-977(1988) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains."
Biochem. Biophys. Res. Commun. 165:735-741(1989) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor."
J. Biol. Chem. 277:33571-33579(2002) [PubMed] [Europe PMC] [Abstract]

"Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A."
Biochem. Biophys. Res. Commun. 350:430-436(2006) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]