Nerve Growth Factor IB (NGFIB)

GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3; DHR38; TIS1; Orphan nuclear receptor HMR; Testicular receptor 3; Nuclear receptor subfamily 4 group A member 1

SPN	S826
HGNC	7980
MGI	1352454
RGD	620029
UniProt	P22736

NGFIB plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the NGFIB protein appears to play a key role in the survival and death of cells.Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, encoding the same protein, have been identified.The protein has an atypical ligand-binding domain that is unlike the classical ligand-binding domain in most nuclear receptors. The classical domain contains a ligand-receiving pocket and co-activator site, both of which are lacking in the NR4A family. Where most nuclear receptors have a hydrophobic surface that results in a cleft, NGFI-B has a hydrophilic surface.

Reference

"A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily."
Mol. Endocrinol. 4:1438-1443(1990) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily."
J. Steroid Biochem. 34:391-395(1989) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phorbol ester, forskolin, and serum induction of a human colon nuclear hormone receptor gene related to the NUR 77/NGFI-B genes."
Cell Growth Differ. 2:203-208(1991) [PubMed] [Europe PMC] [Abstract]

"Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB."
Nucleic Acids Res. 32:5280-5290(2004) [PubMed] [Europe PMC] [Abstract]

"CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation."
Mol. Endocrinol. 19:12-24(2005) [PubMed] [Europe PMC] [Abstract]

"RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation."
J. Biol. Chem. 282:14056-14064(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1."
Biochem. Pharmacol. 80:867-873(2010) [PubMed] [Europe PMC] [Abstract]

"The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK."
Nat. Chem. Biol. 8:897-904(2012) [PubMed] [Europe PMC] [Abstract]