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Cathepsin G (CTSG)

CG; CTS-G

Neutrophilic polymorphonuclear leukocytes contain specialized azurophil granules whose contents, including the serine proteases cathepsin G and elastase, may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Cathepsin G is a 26,000-Da protease.
Cathepsin G isa member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Hu01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Hu01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Hu01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Hu01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Hu01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Mu01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Mu01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Mu01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Mu01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Mu01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Ra01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Ra01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Ra01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Ra01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Ra01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Ca01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Ca01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Ca01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Ca01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Ca01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Po01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Po01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Po01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Po01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Po01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Bo01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Bo01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Bo01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Bo01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Bo01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Rb01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Rb01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Rb01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Rb01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Rb01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS796Mo01 Recombinant Cathepsin G (CTSG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS796Mo01 Monoclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IP.
PAS796Mo01 Polyclonal Antibody to Cathepsin G (CTSG) WB; IHC; ICC; IF.
Assay Kits CLS796Mo01 CLIA Kit for Cathepsin G (CTSG) CLIA assay for Antigen Detection
ELS796Mo01 ELISA Kit for Cathepsin G (CTSG) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases."
Biochemistry 26:2289-2293(1987) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and chromosomal localization of the human cathepsin G gene."
J. Biol. Chem. 264:13412-13419(1989) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of the U-937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G."
FEBS Lett. 345:81-86(1994) [PubMed] [Europe PMC] [Abstract]

"Isolation, characterization, and amino-terminal amino acid sequence analysis of human neutrophil cathepsin G from normal donors."
Anal. Biochem. 158:217-227(1986) [PubMed] [Europe PMC] [Abstract]

"Antibiotic proteins of human polymorphonuclear leukocytes."
Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]

"Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G."
J. Immunol. 147:921-926(1991) [PubMed] [Europe PMC] [Abstract]

"Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis."
J. Immunol. Methods 180:25-33(1995) [PubMed] [Europe PMC] [Abstract]

"Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa."
Infect. Immun. 59:4193-4200(1991) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"The 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities."
EMBO J. 15:5481-5491(1996) [PubMed] [Europe PMC] [Abstract]

, Submitted (SEP-1997) to the PDB data bank

"Sequence variant of the human cathepsin G gene."
Hum. Genet. 91:83-84(1993) [PubMed] [Europe PMC] [Abstract]