CREB Regulated Transcription Coactivator 3 (CRTC3)

TORC3; Transducer of regulated cAMP response element-binding protein 3

SPN	S788
HGNC	26148
MGI	1917711
PubMed	21164481
RGD	1309666
UniProt	Q6UUV7
Wiki	CRTC3

By searching databases for sequences similar to TORC1 (MECT1), Iourgenko et al. (2003) identified TORC3. The deduced 618-amino acid protein contains an N-terminal coiled-coil domain and a protein kinase A phosphorylation site. TORC3 shares 32% amino acid identity with TORC1.

By cotransfection of TORC3 and reporter genes in HeLa cells, Iourgenko et al. (2003) found that TORC3 potently activated expression of genes driven by the IL8 promoter or a promoter carrying multiple CRE-like sequences.Forced expression of these TORCs in mouse primary muscle cells induced endogenous Pgc1-alpha and its target genes, resulting in increased mitochondrial oxidative capacity.

Reference

"Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells."
Proc. Natl. Acad. Sci. U.S.A. 100:12147-12152(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TORCs: transducers of regulated CREB activity."
Mol. Cell 12:413-423(2003) [PubMed] [Europe PMC] [Abstract]

"The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector."
Cell 119:61-74(2004) [PubMed] [Europe PMC] [Abstract]

"Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3."
J. Biol. Chem. 279:52978-52983(2004) [PubMed] [Europe PMC] [Abstract]

"Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins."
Curr. Biol. 14:2156-2161(2004) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
FEBS J. 273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]

"TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats."
J. Virol. 80:7052-7059(2006) [PubMed] [Europe PMC] [Abstract]

"Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells."
Proc. Natl. Acad. Sci. U.S.A. 103:14379-14384(2006) [PubMed] [Europe PMC] [Abstract]

"BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3."
J. Biol. Chem. 282:28335-28343(2007) [PubMed] [Europe PMC] [Abstract]

"Dephosphorylation of TORC initiates expression of the StAR gene."
Mol. Cell. Endocrinol. 265:196-204(2007) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]