Cannabinoid Receptor 2, Macrophage (CNR2)

CB2; CX5

SPN	S736
HGNC	2160
MGI	104650
PubMed	11479216
RGD	619713
UniProt	P34972
Wiki	CNR2

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Cannabinoid receptor 2 is a G protein-coupled receptor from the cannabinoid receptor family. It is closely related to the cannabinoid receptor 1 which is responsible for the psychoactive properties of tetrahydrocannabinol, the active principle of marijuana.

Reference

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