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Protocadherin 15 (PCDH15)

USH1F; DFNB23; CDHR15; Deafness,Autosomal Recessive 23; Cadherin-Related Family Member 15

PCSH15 encodes a variety of isoforms with 3 to 11 ectodomains, a transmembrane domain, and a C-terminal cytoplasmic domain (CD). The amino acid sequences of CD1, CD2, and CD3 are entirely different. PCDH15-CD1 showed a limited pattern of expression and was detected in human testis, retina, and cochlea. PCDH15-CD2 expression was present in the human heart, kidney, thymus, spleen, testis, retina and cochlea. PCDH15-CD3 was widely transcribed and detected in almost all of 18 tissues tested. PCDH15 expression in the inner and outer synaptic layers and the nerve fiber layer in human adult and fetal retinas. Additional reactivity in the region of the outer limiting membrane/photoreceptor cell inner segments was observed in adult but not fetal retina.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Hu01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Hu01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Hu01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Hu01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Hu01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Mu01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Mu01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Mu01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Mu01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Mu01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Ra01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Ra01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Ra01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Ra01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Ra01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Ca01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Ca01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Ca01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Ca01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Ca01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Po01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Po01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Po01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Po01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Po01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Bo01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Bo01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Bo01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Bo01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Bo01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Rb01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Rb01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Rb01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Rb01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Rb01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPS686Mo01 Recombinant Protocadherin 15 (PCDH15) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAS686Mo01 Monoclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IP.
PAS686Mo01 Polyclonal Antibody to Protocadherin 15 (PCDH15) WB; IHC; ICC; IF.
Assay Kits CLS686Mo01 CLIA Kit for Protocadherin 15 (PCDH15) CLIA assay for Antigen Detection
ELS686Mo01 ELISA Kit for Protocadherin 15 (PCDH15) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F."
Hum. Mol. Genet. 10:1709-1718(2001) [PubMed] [Europe PMC] [Abstract]

"Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F."
Am. J. Hum. Genet. 69:25-34(2001) [PubMed] [Europe PMC] [Abstract]

"PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23."
Hum. Mol. Genet. 12:3215-3223(2003) [PubMed] [Europe PMC] [Abstract]

"Gene structure and mutant alleles of PCDH15: nonsyndromic deafness DFNB23 and type 1 Usher syndrome."
Hum. Genet. 124:215-223(2008) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas."
Oncogene 25:2807-2811(2006) [PubMed] [Europe PMC] [Abstract]

"Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population."
Hum. Genet. 116:292-299(2005) [PubMed] [Europe PMC] [Abstract]

"Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans."
Hum. Mol. Genet. 14:103-111(2005) [PubMed] [Europe PMC] [Abstract]

"Mutation screening of the PCDH15 gene in Spanish patients with Usher syndrome type I."
Mol. Vis. 18:1719-1726(2012) [PubMed] [Europe PMC] [Abstract]