Ephrin A5 (EFNA5)
AF1; EFL5; EPLG7; GLC1M; LERK7; RAGS; AL-1; EPH-related receptor tyrosine kinase ligand 7
Ephrin-A5prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Hu01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Hu01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Hu01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Hu01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Hu01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Mu01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Mu01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Mu01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Mu01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Mu01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Ra01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Ra01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Ra01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Ra01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Ra01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Ca01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Ca01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Ca01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Ca01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Ca01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Po01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Po01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Po01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Po01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Po01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Bo01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Bo01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Bo01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Bo01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Bo01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Rb01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Rb01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Rb01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Rb01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Rb01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS670Mo01 | Recombinant Ephrin A5 (EFNA5) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS670Mo01 | Monoclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IP. |
| PAS670Mo01 | Polyclonal Antibody to Ephrin A5 (EFNA5) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS670Mo01 | CLIA Kit for Ephrin A5 (EFNA5) | CLIA assay for Antigen Detection |
| ELS670Mo01 | ELISA Kit for Ephrin A5 (EFNA5) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation."
Neuron 14:973-981(1995) [PubMed] [Europe PMC] [Abstract]
"LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain."
Cytokine 9:540-549(1997) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion."
Genes Dev. 13:3125-3135(1999) [PubMed] [Europe PMC] [Abstract]
"Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling."
J. Cell Sci. 115:1059-1072(2002) [PubMed] [Europe PMC] [Abstract]
"Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."
Cell 123:291-304(2005) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human ephrin-A5 ectodomain."
Protein Sci. 16:996-1000(2007) [PubMed] [Europe PMC] [Abstract]