Ephrin Type B Receptor 3 (EPHB3)
ETK2; HEK2; TYRO6; EPH-like tyrosine kinase 2; Embryonic kinase 2; Tyrosine-protein kinase TYRO6
Ephrin type-B receptor 3 is a protein encoded by the EPHB3 gene.Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Hu01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Hu01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Hu01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Hu01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Hu01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Mu01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Mu01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Mu01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Mu01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Mu01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Ra01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Ra01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Ra01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Ra01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Ra01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Ca01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Ca01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Ca01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Ca01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Ca01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Po01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Po01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Po01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Po01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Po01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Bo01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Bo01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Bo01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Bo01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Bo01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Rb01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Rb01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Rb01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Rb01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Rb01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS663Mo01 | Recombinant Ephrin Type B Receptor 3 (EPHB3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS663Mo01 | Monoclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IP. |
| PAS663Mo01 | Polyclonal Antibody to Ephrin Type B Receptor 3 (EPHB3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS663Mo01 | CLIA Kit for Ephrin Type B Receptor 3 (EPHB3) | CLIA assay for Antigen Detection |
| ELS663Mo01 | ELISA Kit for Ephrin Type B Receptor 3 (EPHB3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2."
Oncogene 8:2857-2862(1993) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Unified nomenclature for Eph family receptors and their ligands, the ephrins."
Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]
"Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions."
Oncogene 17:255-260(1998) [PubMed] [Europe PMC] [Abstract]
"Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases."
J. Biol. Chem. 280:923-932(2005) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Ligand binding domain of human EPHB3."
Submitted (JAN-2011) to the PDB data bank
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]