Ephrin Type A Receptor 4 (EPHA4)

HEK8; SEK; TYRO1; EPH-like kinase 8; Tyrosine-protein kinase receptor SEK

SPN	S658
HGNC	3388
MGI	98277
PubMed	22922411
RGD	1560587
UniProt	P54764
Wiki	EPHA4

EPH receptor A4 is a protein belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.

Reference

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Oncogene 10:897-905(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Unified nomenclature for Eph family receptors and their ligands, the ephrins."
Cell 90:403-404(1997) [PubMed] [Europe PMC] [Abstract]

"The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."
J. Neurosci. 27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]

"Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
Nat. Neurosci. 10:67-76(2007) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor."
J. Biol. Chem. 283:29473-29484(2008) [PubMed] [Europe PMC] [Abstract]

"Structural plasticity of EPH receptor A4 facilitates cross-class ephrin signaling."
Structure 17:1386-1397(2009) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity."
J. Biol. Chem. 285:644-654(2010) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]